Veterinary Nhau: Kufambira mberi mukutsvaga kweAvian furuwenza

Nhau 01

Kutanga kuonekwa kweH4N6 subtype yeavian influenza virus mu mallard ducks (Anas platyrhynchos) muIsrael.

Avishai Lublin，Nikki Thie，Irina Shkoda，Luba Simanov，Gila Kahila Bar-Gal，Yigal Farnoushi，Roni King，Wayne M Getz，Pauline L Kamath，Rauri CK Bowie，Ran Nathan

PMID:35687561;DOI：10.1111/tbed.14610

Avian influenza virus (AIV) inotyisidzira zvakanyanya kuhutano hwemhuka uye hwevanhu pasi rese.Sezvo shiri dzemusango dzichiparadzira AIV pasi rese, kuongorora kuwanda kweAIV muvanhu vemusango kwakakosha kuti tinzwisise kutapurirana kwepathogen uye kufanotaura kubuda kwechirwere mumhuka dzemumba nevanhu.Muchidzidzo ichi, H4N6 subtype AIV yakaparadzaniswa kekutanga kubva kune tsvina yemadhadha emusango (Anas platyrhynchos) muIsrael.phylogenetic mhedzisiro yeHA uye NA genes inoratidza kuti dhizaini iyi yakabatana zvakanyanya neEuropean neAsia.Sezvo Israeri iri pedyo neMiddle Arctic-Africa nzira inotama, zvinofungidzirwa kuti rudzi urwu rungangodaro rwakaunzwa neshiri dzinotama.Kuongororwa kwePhylogenetic kwemajini emukati ega ega (PB1, PB2, PA, NP, M uye NS) yakaratidza hupamhi hwehukama hwefilogenetic kune mamwe maAIV subtypes, zvichiratidza kuti chiitiko chekare chekudzokorora chakaitika munzvimbo iyi yega.Iyi H4N6 subtype yeAIV ine yakakwirira recombination rate, inogona kukanganisa nguruve dzine hutano uye kusunga vanhu vanogamuchira, uye inogona kukonzera zoonotic chirwere mune ramangwana.

Nhau 02

Mhedziso yeavian influenza muEU, Kurume-Chikumi 2022

European Food Safety Authority, European Center for Disease Prevention and Control, European Union Reference Laboratory yeAvian Influenza.

PMID：35949938;PMCID：PMC9356771;DOI：10.2903/j.efsa.2022.7415;

Muna 2021-2022, yakanyanya pathogenic avian influenza (HPAI) ndiyo yaive denda rakaipisisa muEurope, paine 2,398 avian kubuda munyika makumi matatu nenhanhatu dzeEurope zvichikonzera kuti shiri dzinosvika mamirioni makumi mana nematanhatu dziurawe.pakati paKurume 16 naChikumi 10, 2022, nyika makumi maviri nesere dzeEU/EEA uye UK 1182 mhando dzehutachiona hweavian influenza virus (HPAIV) dzakaparadzaniswa kubva kune huku (750 kesi), mhuka dzesango (410 kesi) uye shiri dzakatapwa (22). nyaya).Munguva iri kuongororwa, 86% yehuku dzakaputika dzakakonzerwa nekutapurirana kweHPAIV, neFrance ichiverengera makumi matanhatu nesere muzana yehuku dzese dzakabuda, Hungary ye24% uye dzimwe nyika dzakakanganisika isingasviki 2% imwe neimwe.Germany yaive nehuwandu hwepamusoro hwekubuda kweshiri dzesango (158 kesi), ichiteverwa neNetherlands (98 kesi) uye UK (48 kesi).

Mhedzisiro yekuongorora kwemajini inoratidza kuti HPAIV parizvino iri muEurope zvakanyanya ndeye spectrum 2.3.4 b.Kubva pamushumo wekupedzisira, mana H5N6, maviri H9N2 uye maviri H3N8 hutachiona hwevanhu zvakataurwa muChina uye imwe H5N1 hutachiona hwevanhu yakashumwa muUSA.Ngozi yekutapukirwa yakaonekwa seyakaderera kune ruzhinji uye yakaderera kusvika pakati nepakati kune vanhu vakafumurwa mabasa muEU/EEA.

 Nhau 03

Shanduko pane zvakasara 127, 183 uye 212 paHA gene inokanganisa

Antigenicity, kudzokorora uye pathogenicity yeH9N2 avian influenza virus

Menglu Fan,Bing Liang,Yongzhen Zhao,Yaping Zhang,Qingzheng Liu,Miao Tian,Yiqing Zheng,Huizhi Xia,Yasuo Suzuki,Hualan Chen,Jihui Ping

PMID:34724348;DOI：10.1111/tbed.14363;

H9N2 subtype yeavian influenza virus (AIV) ndeimwe yemhando huru inokanganisa hutano hweindasitiri yehuku.Muchidzidzo ichi, marudzi maviri eH9N2 subtype AIV ane genetic background asi akasiyana antigenicity, anonzi A/chicken/Jiangsu/75/2018 (JS/75) uye A/chicken/Jiangsu/76/2018 (JS/76), aiva kure kure nepurazi rehuku.Sequence analysis yakaratidza kuti JS/75 uye JS/76 dzakasiyana mumatatu amino acid residues (127, 183 uye 212) yehemagglutinin (HA).Kuti uongorore kusiyana kwezvinhu zvipenyu pakati peJS / 75 neJS / 76, mavhairasi matanhatu ekubatanidza akagadzirwa achishandisa reverse genetic approach neA / Puerto Rico / 8 / 1934 (PR8) seketani huru.Dhata kubva kuhuku kurwisa bvunzo uye HI bvunzo dzakaratidza kuti r-76/PR8 yakaratidza yakanyanya kutaurwa antigenic kutiza nekuda kweamino acid mutations panzvimbo 127 uye 183 muHA gene.Zvimwe zvidzidzo zvakasimbisa kuti glycosylation panzvimbo ye127N yakaitika muJS / 76 uye kuchinja kwayo.Receptor binding assays yakaratidza kuti ese mavhairasi anodzokororwa, kunze kwe127N glycosylation-deficient mutant, anosungwa zviri nyore kune humanoid receptors.Kukura kinetics uye mouse attack assays yakaratidza kuti 127N-glycosylated virus yakadzokorora zvishoma mumasero eA549 uye yakanga isina pathogenic mumakonzo kana ichienzaniswa nehutachiona hwemhando yemhuka.Nokudaro, glycosylation uye amino acid mutations muHA gene inokonzera kusiyana kweantigenicity uye pathogenicity ye2 H9N2 strains.

Kwakabva: China Animal Health uye Epidemiology Center